Therivapeutics LLC

Mission Statement

Research and development of innovative therapeutic solutions, providing scientific services including in silico design, screening, testing, and consulting; collaborating with for-profit and non-profit organizations to accelerate discovery and development in the biotechnology sector.

Meet the founder & CEO

I am Ravindra Thakkar, PhD, the Founder and CEO of Therivapeutics LLC, bringing over a decade of experience in structural biology and biomolecular modelling

My work integrates experimental and computational approaches in structural biology, with a focus on computational biomolecular modeling and electron microscopy for therapeutic applications. Leveraging my expertise in protein structural biology and structure/function relationships, I have successfully designed de novo therapeutic peptides using Rosetta and predicted their molecular interactions through molecular docking and MD simulations and free energy calculations using NAMD and Gromacs. Further I have validated protein-protein interactions with their respective receptor proteins using Biolayer interferometry (BLI) and cryoEM single particle analysis. Additionally, I have obtained an international patent for a designed cyclic peptide used in cancer immunotherapy. This achievement demonstrates my ability to translate scientific research into tangible outcomes with the potential to improve patient lives.

I am a skilled electron microscopist with specialized expertise in applications across structural biology, clinical pathology, general biological and soft material research including nanomaterial characterization. I have extensive experience in studying morphological changes in cells and organelles under various disease states and experimental conditions, as well as in identifying viral and bacterial deposits in animal and plant tissues under infectious conditions

I am passionate about building partnerships to tackle complex challenges that improve human health and benefit society and served on collaborative projects with have worked with Sanofi, Altos Lab, Syrna Therapeutics, Charles-River Laboratories and many more.

Need more informations, please feel free to email us therivapeutics@gmail.com

Consultation & Services in Molecular Modeling & Computational Biology

Molecular docking including post docking analysis (Docking score, RMSD, 2D & 3D interaction plots)
Molecular dynamics simulations including post simulation analysis (RMSD, PCA, RMSF, MMGBSA, interatomic-distance)
Protein structure prediction and analysis including model validation
Binding free energy estimation
High-throughput in silico screening
ADMET analysis

Consultation & On-site Training in Biological Electron Microscopy

Operation of Transmission Electron Microscope (TEM) and Scanning Electron Microscope (SEM) including basic maintenance and calibration.
Traditional biological specimen preparation for TEM and SEM analysis.
Ultramicrotomy of resin embedded specimens for TEM analysis.

A few selected publications

Computational design of a cyclic peptide that inhibits the CTLA4 immune checkpoint

Thakkar, Ravindra and Upreti, Deepa and Ishiguro, Susumu and Tamura, Masaaki and Comer, Jeffrey

RSC Medicinal Chemistry, 2023

DOI

De novo design of a stapled peptide targeting SARS-CoV2 spike protein receptor-binding domain.

Ravindra Thakkar, Dilip K. Agarwal, Chathuranga B. Ranaweera, Susumu Ishiguro, Martin Conda-Sheridan, Natasha N. Gaudreault, Juergen A. Richt, Masaaki Tamura, and Jeffrey Comer

RSC Medicinal Chemistry, 2023

DOI